QUALITY CONTROL OF 2% KETOCONAZOLE SHAMPOOS IN COMPOUNDING PHARMACIES IN PORTO VELHO, RO, BRAZIL
Abstract
Shampoos are products for cleaning or fixation of substances with dermatological action. Ketoconazole shampoos have the purpose of treating and preventing fungal infections caused by Malassezia globosa. Due to these are high-consumption shampoos it is necessary to confirm the quality of the products handled in the compounding pharmacies. The objective of this work was to perform quality analyzes of the ketoconazole shampoos from compounding pharmacies in Porto Velho, RO. Organoleptic analyzes, hydrogenionic potential (pH), density determination, viscosity, foaming potential, centrifugation test, and spectrophotometric assay were performed. The five samples were satisfactory for the organoleptic analysis; about pH, only sample B fit within the standards. About density, samples A and C were satisfactory. Considering viscosity, only E was unsatisfactory; and foaming power and dosing were not acceptable for samples D and E. In the centrifugation test formulations A, D and E produced precipitation.
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PDF (Português (Brasil))DOI: http://dx.doi.org/10.14450/2318-9312.v31.e3.a2019.pp155-162
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Copyright (c) 2019 EVA MARIA XAVIER LOPES, Fábio Lopes Moreira de Castilho, Victória Carolina Freire de Castro
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Infarma - Ciências Farmacêuticas
ISSN - 2318-9312 (Versão eletrônica)
ISSN - 0104-0219 (Versão impressa)
Conselho Federal de Farmácia - CFF
SHIS QI 15 Lote "L" - Lago Sul - Brasília - DF
CEP: 71635-615 - Fone: (61)3878-8751
e-mail:infarma@cff.org.br
Diretoria
Walter da Silva Jorge João, Presidente do Conselho Federal de Farmácia
Lenira da Silva Costa, Vice-Presidente do Conselho Federal de Farmácia
João Samuel de Morais Meira, Tesoureiro do Conselho Federal de Farmácia
Luiz Gustavo de Freitas Pires, Secretário-Geral do Conselho Federal de Farmácia