QUALITY OF SIBUTRAMINE CAPSULES MANIPULATED BY THREE COMPOUNDING PHARMACIES IN BELO HORIZONTE, MG, BRAZIL
Abstract
Sibutramine is indicated as an anorectic drug of choice for the treatment of obesity. Due to lack of pharmacopoeia monographs for analysis and quality control of this drug and that sibutramine has classification biopharmaceutical I, the authors of this study proposed physical-chemical tests of quality and evaluation of the influence of excipients in dissolving sibutramine capsules 10 mg manipulated in three compounding pharmacies of Belo Horizonte, MG. The general methods described in the Brazilian Pharmacopoeia 5th ed were applied and was made co-validation of UV spectrophotometric method. The results indicate that only one of the three samples fulfilled all quality specifications.
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PDF (Português (Brasil))DOI: http://dx.doi.org/10.14450/2318-9312.v27.e4.a2015.pp226-233
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Copyright (c) 2016 Grazielle Heloiza Sanguinete, Isaias de Paula Campos Neto, Ivanete Aparecida Rodrigues Gonçalves, Maria Betânia de Freitas Marques
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Infarma - Ciências Farmacêuticas
ISSN - 2318-9312 (Versão eletrônica)
ISSN - 0104-0219 (Versão impressa)
Conselho Federal de Farmácia - CFF
SHIS QI 15 Lote "L" - Lago Sul - Brasília - DF
CEP: 71635-615 - Fone: (61)3878-8751
e-mail:infarma@cff.org.br
Diretoria
Walter da Silva Jorge João, Presidente do Conselho Federal de Farmácia
Lenira da Silva Costa, Vice-Presidente do Conselho Federal de Farmácia
João Samuel de Morais Meira, Tesoureiro do Conselho Federal de Farmácia
Luiz Gustavo de Freitas Pires, Secretário-Geral do Conselho Federal de Farmácia