PHARMACEUTICAL EQUIVALENCE STUDY BETWEEN SIMILAR AND GENERIC FUROSEMIDE PILLS
Abstract
Furosemide is a medicine widely used in hypertensive therapy, congestive heart failure, oedema of cardiac, renal and hepatic origin. Because it is a loop diuretic, due to its role in the thick segment of the Henle loop, it is considered very potent for these diseases. Pharmaceutical equivalence aims to promote comparative quality tests between the reference drug and the drug to be tested. Test and reference medicinal products must present the same concentrations, pharmaceutical forms, physical and physicochemical characteristics. In this study, the drug furosemide 40 mg was used, where two generic brands were tested (G1 and G2), and two similar ones (S1 and S2) comparing them with the reference (R). Regarding weight variation, friability, disintegration, hardness, dissolution, dosing and the total number of mesophilic microorganisms, it can be said that the drugs are pharmaceutical equivalents.
Keywords
pharmaceutical equivalence; furosemide; generic; similar drug
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PDF (Português (Brasil))DOI: http://dx.doi.org/10.14450/2318-9312.v32.e1.a2020.pp77-85
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Copyright (c) 2020 Murilo Neth de Sousa, Thalita Prates da Silva, Emilly Isabelli dos Santos Teodoro, Mariana Aparecida Lopes-Ortiz, João Carlos Palazzo de Mello, Daniela Cristina de Medeiros Araújo
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Infarma - Ciências Farmacêuticas
ISSN - 2318-9312 (Versão eletrônica)
ISSN - 0104-0219 (Versão impressa)
Conselho Federal de Farmácia - CFF
SHIS QI 15 Lote "L" - Lago Sul - Brasília - DF
CEP: 71635-615 - Fone: (61)3878-8751
e-mail:infarma@cff.org.br
Diretoria
Walter da Silva Jorge João, Presidente do Conselho Federal de Farmácia
Lenira da Silva Costa, Vice-Presidente do Conselho Federal de Farmácia
João Samuel de Morais Meira, Tesoureiro do Conselho Federal de Farmácia
Luiz Gustavo de Freitas Pires, Secretário-Geral do Conselho Federal de Farmácia