The use of Cannabis sativa L. cannabinoids in the treatment of epilepsy: a narrative review
Abstract
The use of Cannabis sativa for medicinal purposes is a very controversial subject in Brazil, so it is necessary to delve deeper into the theme to elucidate the main questions and possible benefi ts. Epilepsy is a disease
that causes neurological changes, such as epileptic seizures, dysphagia and convulsions. It can lead to cognitive and psychological damage and comorbidities, worsening the patient's quality of life. In this study an integrative review was carried out about the different types of C. sativa cannabinoids and their use for treating epilepsy. The data were obtained from research articles published in periodicals between 1963 and 2020. Special attention was given to different metabolites, such as cannabidiol (CBD). General aspects of epilepsy, phytocannabinoid use in refractory cases and clinical and pre-clinical trials were addressed in this review, emphasizing their biological effects. As a future target for treating epilepsy, the therapeutic use of CBD in neurology shows promising results in cases where the conventional medication has no effect. A contribution of research on other phytocannabinoids and their interrelationship is essential to advance the treatment of epilepsy and other pathologies.
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PDF (Português (Brasil))DOI: http://dx.doi.org/10.14450/2318-9312.v34.e1.a2022.pp25-33
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Copyright (c) 2022 Lucas Alonso Lopes, Bruno Paes De-Carli, Caio Silva Moura, Agatha Manzi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Infarma - Ciências Farmacêuticas
ISSN - 2318-9312 (Versão eletrônica)
ISSN - 0104-0219 (Versão impressa)
Conselho Federal de Farmácia - CFF
SHIS QI 15 Lote "L" - Lago Sul - Brasília - DF
CEP: 71635-615 - Fone: (61)3878-8751
e-mail:infarma@cff.org.br
Diretoria
Walter da Silva Jorge João, Presidente do Conselho Federal de Farmácia
Lenira da Silva Costa, Vice-Presidente do Conselho Federal de Farmácia
João Samuel de Morais Meira, Tesoureiro do Conselho Federal de Farmácia
Luiz Gustavo de Freitas Pires, Secretário-Geral do Conselho Federal de Farmácia