Analysis of adverse reactions to medications in patients admitted to a tertiary public hospital in Brazil: Descriptive study

Authors

  • Carolina Broco Manin Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010 https://orcid.org/0000-0002-7361-6127
  • Larissa Leite Rienesl Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010 https://orcid.org/0009-0000-3847-9318
  • Maria Alice Pimentel Falcão Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010 https://orcid.org/0000-0003-3097-6285
  • Vanusa Barbosa Pinto Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010 https://orcid.org/0000-0002-7463-5266

DOI:

https://doi.org/10.14450/2318-9312.v37.e1.a2025.pp104-112

Keywords:

Pharmacovigilance, Adverse reaction, Patient safety

Abstract

Objective: This study analyzed the adverse reactions of patients admitted to a high-complexity hospital belonging to the Sentinel Network with the aim of understanding the medications that most cause adverse reactions. Method: This is a retrospective ecological descriptive study, carried out in a large tertiary hospital, located in the state of São Paulo, in which adverse reactions included in the VigiMed system between August 2019 and August 2022 were analyzed. spontaneous notifications, as well as active  searches carried out by the pharmacovigilance sector itself. Data analysis was carried out using Excel® 2016  spreadsheets. A total of 682 reports of suspected adverse
reactions were analyzed. Results and Conclusion:
In terms of gender distribution, 49.41% of notifications
corresponded to male patients and 50.59% to female patients. The notifications were also distributed by age group, with emphasis on the group of adults (from 19 to 59 years old) with 58.65%. Serious reactions accounted for 48.02% and non-serious reactions for 48.58%. 993 suspected medications were identified and the most reported 
belonged to group J - antimicrobials for systemic use (35.45%) and group N (24.17%), medications for the nervous system and the third most reported group was B (14.60%), blood and hematopoietic organs. Using the data obtained in this study, it is possible to define some actions to minimize preventable adverse reactions.

Author Biographies

Carolina Broco Manin, Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010

Divisão de Farmácia do Instituto Central do Hospital das clínicas de São Paulo

Área - Farmacovigilância

Larissa Leite Rienesl, Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010

Divisão de Farmácia do Instituto Central do Hospital das clínicas de São Paulo

Área - Farmacovigilância

Maria Alice Pimentel Falcão, Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010

Divisão de Farmácia do Instituto Central do Hospital das clínicas de São Paulo

Área - Centro de Informação de Medicamentos

Vanusa Barbosa Pinto, Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo Av. Dr Enéas de Carvalho Aguiar, 155 8º andar Prédio dos Ambulatórios Cerqueira César São Paulo CEP 05403-010

Divisão de Farmácia do Instituto Central do Hospital das Clínicas da Universidade de São Paulo

Diretora de Divisão

Downloads

Published

2026-03-31

How to Cite

Manin, C. B., Rienesl, L. L., Falcão, M. A. P., & Pinto, V. B. (2026). Analysis of adverse reactions to medications in patients admitted to a tertiary public hospital in Brazil: Descriptive study. Infarma - Pharmaceutical Sciences, 37(1), 104–112. https://doi.org/10.14450/2318-9312.v37.e1.a2025.pp104-112

Issue

Vol. 37 No. 1 (2025)

Section

Original article

License

Copyright (c) 2026 Carolina Broco Manin, Larissa Leite Rienesl, Maria Alice Pimentel Falcão, Vanusa Barbosa Pinto

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who publish in this journal agree to the following terms:

 

  1. Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Licença Creative Commons Attribution which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
  2. Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (e.g. publish in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal.
  3. Authors are allowed and encouraged to publish and distribute their work online (e.g. in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and Citation of published work (See O Efeito do Acesso Livre ).

Similar Articles

You may also start an advanced similarity search for this article.