EVALUATION OF CAPTOPRIL CONTENT UNIFORMITY IN CAPSULES AND TABLETS SOLD IN PHARMACIES AND DRUGSTORES FROM VOTUPORANGA, SP, BRAZIL.

Authors

  • Gabriela Oliveira Rodrigues Nascimento Centro Universitário de Votuporanga - Unifev - Rua Pernambuco, 4196 - Centro - Votuporanga – SP
  • Ely Edurado Saranz Camargo Laquanaturis - Cursos Profissionalizantes Ltda. e Instituto de Pesquisa. Rua Capitão José Verdi, 244, Boa Vista, São José do Rio Preto – SP http://orcid.org/0000-0002-5215-2116

DOI:

https://doi.org/10.14450/2318-9312.v27.e4.a2015.pp234-238

Keywords:

captopril, quality control, efficacy, uniform content

Abstract

Captopril is a drug indicated for the treatment of arterial hypertension (AH) and heart failure (HF), and the first drug developed from the synthesis of the venom of the snake Bothrops jararaca. It is used as a prototype for other substances for the control high blood pressure. In the Brazilian Health System (SUS), captopril is inserted in the National List of Essential Medicines (Rename); it is also quoted in almost all County Lists of Essential Medicines (Remumes). The aimof this study was to evaluate the content uniformity in tablets and capsules containing captopril at a concentration of 25mg. Samples were from industries (reference, generic and similar), and also manipulated in compounding pharmacies atVotuporanga, SP. The study was based on quality concept applied to obedience to the law. The results showed variationsin drug concentration when compared to the reference product (25 mg). The range was from 69 % (lower concentration)to 112 %. Thus, the results showed the evidence of the lack of quality control, uniformity of content for the evaluatedpharmaceutical dosage forms, which may compromise the effectiveness and safety for the patient.

Author Biographies

Gabriela Oliveira Rodrigues Nascimento, Centro Universitário de Votuporanga - Unifev - Rua Pernambuco, 4196 - Centro - Votuporanga – SP

Farmacêutica, graduada pelo Centro Universitário de Votuporanga - SP, trabalhou na drogaria Araujo na cidade de Jales - SP e atualmete desenvolve pesquisa no Laboratório Cristália em Itapira - SP.

 

Ely Edurado Saranz Camargo, Laquanaturis - Cursos Profissionalizantes Ltda. e Instituto de Pesquisa. Rua Capitão José Verdi, 244, Boa Vista, São José do Rio Preto – SP

Graduated in Pharmacy from Universidade Metodista de Piracicaba (1991), masters in Pharmaceutical Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho, with a focus in Research and Development of Drugs and Medicines (2001) and PhD in Pharmaceutical Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho, with a focus in Pharmacy (2010). Elected federal deputy councilor of the Federal Pharmaceutical Council at the State of São Paulo, for the 2004/2007 term, and became a fully empowered councilor in May 2005. Elected federal councilor at the State of São Paulo for the 2008/2011, where he chaired the Technical Groups of Herbal Medicine and Pharmaceutical industry. Elected director of the Union of Pharmacists in the State of São Paulo for several terms from 2001 to the present day.  Coordinated the course of pharmacy at Universidade Paulista - UNIP from 1998 to 2003. Professor at Fundação Educacional de Fernandópolis - FEF 1998/2010 where he taught the disciplines of Pharmacotechnics, Homeopathy, Cosmetology, Deontology and Pharmaceutical Legislation and pharmaceutical legislation and Pharmaceutical Assistance.  Professor at Centro Universitário de Votuporanga - UNIFEV in the 2009/2012 period, where he taught the disciplines of pharmaceutical technology, pharmaceutical chemistry and methodology of scientific research. Is currently a professor at Centro Universitário do Norte Paulista - UNORP teaching the disciplines of Pharmaceutical Technology, Pharmaceutical Chemistry and Pharmacognosy. Coordinates updating and specialization courses at IPCS - Instituto de Pesquisa em Ciências da Saúde, where he holds the position of director since 2008. Has experience in the following segments of Pharmacy:  Development of Drugs and Medicines, Quality Control of Drugs and Medicines, Research and Development of Pharmaceutical Products and Cosmetics. In herbal medicine has experience in Isolation and Identification of Organic Compounds, Pharmaceutical Assistance and Public Policies.

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Published

2016-01-06

How to Cite

Nascimento, G. O. R., & Camargo, E. E. S. (2016). EVALUATION OF CAPTOPRIL CONTENT UNIFORMITY IN CAPSULES AND TABLETS SOLD IN PHARMACIES AND DRUGSTORES FROM VOTUPORANGA, SP, BRAZIL. Infarma - Pharmaceutical Sciences, 27(4), 234–238. https://doi.org/10.14450/2318-9312.v27.e4.a2015.pp234-238

Issue

Vol. 27 No. 4 (2015)

Section

Technical Note

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