ANTIOXIDANT ACTIVITY AND TOXICITY OF EXTRACTS FROM EXOCARP OF NEPHELIUM LAPPACEUM L. (SAPINDACEAE), FROM SALVADOR, BAHIA, BRAZIL.

Authors

  • Aníbal de Freitas Santos Junior Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000 http://orcid.org/0000-0002-3022-0771
  • Leandro Carvalho Oliveira Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000
  • Alessandra da Silva Guedes Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000
  • Milleno Dantas Mota Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000
  • Hemerson Iury Ferreira Magalhaes Universidade Federal da Paraíba (UFPB), Departamento de Ciências Farmacêuticas, Cidade Universitária - João Pessoa/PB - CEP: 58051-900l

DOI:

https://doi.org/10.14450/2318-9312.v28.e3.a2016.pp173-178

Keywords:

Nephelium lappaceum L, fruit, antioxidant, toxicity, Rambutan.

Abstract

Nephelium lappaceum L., known as rambutã, is an attractive tropical fruit, and contains phenolic compounds (tannins and flavonoids) and alkaloids. The aim of this study was to evaluate the antioxidant capacity, by the method of 2.2-diphenyl- 1- picrylhydrazyl (DPPH), and the toxicity to brine shrimp Artemia salina, of Nephelium lappaceum L. (Rambutã) exocarp, marketed in Salvador, Bahia, Brazil, It was used the hexane and ethyl acetate phases, obtained from the ethanol extract partition. For the biological evaluation, 2,2-diphenyl-1-picrylhydrazyl (DPPH) test and toxicity to Artemia salina were used. The ethyl acetate phase showed higher antioxidant power and less toxic effect when compared to hexanic phase. In the DPPH test, ethyl acetate and hexane phases showed EC50 =373.72 μg/mL and 1207.4 μg/ mL, respectively. The hexane phase (LD50=705.72 μg/mL) was more toxic to Artemia salina than ethyl acetate phase (LD50= 799.28 μg/mL). The results indicated the potential use of this fruit (peels) as a natural source of antioxidants.

Author Biographies

Aníbal de Freitas Santos Junior, Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000

PROF. TITULAR DE FARMACOLOGIA, FARMACOLOGIA CLÍNICA E BIOSSEGURANÇA, DO DEPARTAMENTO DE CIÊNCIAS DA VIDA (DCV)

Leandro Carvalho Oliveira, Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000

FARMACEUTICO PELA UNIVERSIDADE DO ESTADO DA BAHIA (UNEB)

Alessandra da Silva Guedes, Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000

PROF. ASSISTENTE DE FARMACOGNOSIA, DO DEPARTAMENTO DE CIÊNCIAS DA VIDA (DCV)

Milleno Dantas Mota, Universidade do Estado da Bahia (UNEB) - Departamento de Ciências da Vida (DCV), Rua Silveira Martins, 2555, Cabula. Salvador-BA. CEP: 41.150-000

PROF. ASSISTENTE DE FARMACOTÉCNICA, DO DEPARTAMENTO DE CIÊNCIAS DA VIDA (DCV)

Hemerson Iury Ferreira Magalhaes, Universidade Federal da Paraíba (UFPB), Departamento de Ciências Farmacêuticas, Cidade Universitária - João Pessoa/PB - CEP: 58051-900l

PROF. ADJUNTO DE TOXICOLOGIA, DO DEPARTAMENTO DE FARMÁCIA

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Published

2016-09-30

How to Cite

Santos Junior, A. de F., Oliveira, L. C., Guedes, A. da S., Mota, M. D., & Magalhaes, H. I. F. (2016). ANTIOXIDANT ACTIVITY AND TOXICITY OF EXTRACTS FROM EXOCARP OF NEPHELIUM LAPPACEUM L. (SAPINDACEAE), FROM SALVADOR, BAHIA, BRAZIL. Infarma - Pharmaceutical Sciences, 28(3), 173–178. https://doi.org/10.14450/2318-9312.v28.e3.a2016.pp173-178

Issue

Vol. 28 No. 3 (2016)

Section

Original article

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