STATIN INTERFERENCE IN LABORATORY EXAMS

Authors

  • Danyelle Cristine Marini Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/
  • Francielen Rita Ferreira Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/
  • Nadia Regina Borim Zuim Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/

DOI:

https://doi.org/10.14450/2318-9312.v29.e1.a2017.pp43-50

Keywords:

Laboratory tests, biochemical, interference, medicines, dyslipidemia

Abstract

Drug interference plays an important role in the laboratory routine because of the probability of interfering with the assays and modifying the clinical-laboratory diagnosis. It is the professional clinical analyst responsible for detecting such interference in order to avoid misdiagnoses and erroneous clinical interventions. The aim of this study was to evaluate the possible interferences of the drug simvastatin in biochemical laboratory tests. A retrospective descriptive study was carried out between April and July 2015. Laboratory tests performed by patients with dyslipidemia and users of a specific drug were evaluated using the services provided by the Municipal Laboratory of Clinical Analysis of Santo Antônio de Posse, SP, Brazil. A questionnaire was applied to the volunteer participants to evaluate the lifestyle and the time of use of the drug. The enzymes Phosphatase Alkaline, Creatinophosphokinase (CPK), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) were analyzed. The results showed that among 43 patients tests, 69.8% presented alterations in at least one of the exams evaluated. There was a change in the ALT enzyme in 53% of the patients test results. However, in 51%, no change in the CPK was detected. The interference of drugs on test results is a real problem due to its wide use throughout the population and proves the need for further studies related to possible interferences in clinical exams.

Author Biographies

Danyelle Cristine Marini, Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/

Possui graduação em Farmácia Habilitação em Farmacêutico pela Universidade Metodista de Piracicaba (1999), doutoranda em educação pela UNIMEP e mestrado em Biologia Celular e Molecular pela Universidade Estadual Paulista Júlio de Mesquita Filho (2005). Atualmente é Conselheira do Conselho Regional de Farmácia de São Paulo, membro da comissão de Educação do Conselho Regional de Farmácia de São Paulo; Professora e coordenadora das Faculdades Integradas Maria Imaculada (FIMI) e Professora do Centro Universitário das Faculdades Associadas de Ensino (UNIFAE). Tem experiência na área de ensino e da assistência farmacêutica.

Francielen Rita Ferreira, Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/

Possui graduação em Farmácia pelas Faculdades Integradas Maria Imaculada (2015),

Nadia Regina Borim Zuim, Faculdades Integradas Maria Imaculada Rua Paula Bueno, 240 Centro Mogi Guaçu - SP CEP 13840050 Telefone 19 38614066 Home page http://mariaimaculada.br/

Doutorado e Mestrado em Parasitologia pela Universidade Estadual de Campinas (UNICAMP). Possui graduação em Ciências Biologia pelas Faculdades Integradas Maria Imaculada. Atualmente é Coordenadora do Curso de Biomedicina e do Curso de Ciências Biologia das Faculdades Integradas Maria Imaculada de Mogi Guaçu/SP. Integrante do Conselho Editorial e de Consultores da Revista FOCO: Caderno de Estudos e Pesquisa. Coordenadora do Comitê de Ética e Pesquisa das FIMI. Membro da Comissão Organizadora de eventos das FIMI desde 2004. Secretária Titular do Comitê Municipal de Combate ao Aedes. Linha de pesquisa Helmintíases transmitidas por moluscos, atuando principalmente nos seguintes temas: Schistosoma mansoni, Biomphalaria glabrata, Biomphalaria tenagophila, esquistossomose mansônica. Tem experiência na área de Parasitologia Básica e Clínica, Epidemiologia, Programas de Saúde, Saúde Pública, Fisiologia e Metodologia Científica.

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Published

2017-04-03

How to Cite

Marini, D. C., Ferreira, F. R., & Zuim, N. R. B. (2017). STATIN INTERFERENCE IN LABORATORY EXAMS. Infarma - Pharmaceutical Sciences, 29(1), 43–50. https://doi.org/10.14450/2318-9312.v29.e1.a2017.pp43-50

Issue

Vol. 29 No. 1 (2017)

Section

Original article

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