Preclinical and clinical studies of selected plant species in Mercosul countries and toxicological aspects

Authors

  • Camile Cecconi Cechinel-Zanchett Programa de Pós-graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí -UNIVALI. Rua Uruguai, 458, CEP 88302-202. Itajaí, SC, Brasil. E-mail: camilecechinel@gmail.com http://orcid.org/0000-0003-3104-560X

DOI:

https://doi.org/10.14450/2318-9312.v29.e4.a2017.pp284-301

Keywords:

phytotherapy, Mercosul, medicinal plants

Abstract

Medicinal plants are used to prevent and treat diseases and have been used by about 80% of the population for primary health care. The rich biodiversity of Brazil and neighboring Countries offers a unique and unparalleled potential for the discovery and development of bioactive agents. This study aimed to do a review of preclinical and clinical studies of herbal and plant species selected from Mercosul countries, and toxicological aspects. Based on previous work, the species with the highesAt number of register in Brazil (Anvisa), Aesculus hippocastanum (Horse Chestnut) and Mikania glomerata (Guaco); the most used as simple herbal medicines in Argentina Cynara scolymus L. (Artichoke) and Solanum dulcamara (Dulcamara); the sold medicinal plants in Paraguay Peumus boldus Mol. (Bilberry), and Borago officinalis (Borage); the most consumed in northern Uruguay Aloe vera (Aloe) and Passiflora edulis (Passion flower) and from Venezuela, Hedera helix (Hera) were selected for a review about pharmacology studies. Surveys on pre-clinical and clinical trials of these species were conducted on Google Scholar, PubMed and Science Direct databases in April 2016, in Portuguese and English. Then the most relevant articles were selected, using animals (rats, rabbits or mice), cellular or bacterial strains or clinical trials. About preclinical and clinical studies, Aloe and Artichoke showed the most substantial number of publications.

Author Biography

Camile Cecconi Cechinel-Zanchett, Programa de Pós-graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí -UNIVALI. Rua Uruguai, 458, CEP 88302-202. Itajaí, SC, Brasil. E-mail: camilecechinel@gmail.com

Doutoranda do Programa de Pós-Graduação em Ciências Farmacêuticas da Univali, na linha de pesquisa de Fitoquímica e Atividade Biológica, na área de Farmacologia do Trato Gastrointestinal.

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Published

2017-12-18

How to Cite

Cechinel-Zanchett, C. C. (2017). Preclinical and clinical studies of selected plant species in Mercosul countries and toxicological aspects. Infarma - Pharmaceutical Sciences, 29(4), 284–301. https://doi.org/10.14450/2318-9312.v29.e4.a2017.pp284-301

Issue

Vol. 29 No. 4 (2017)

Section

Review Article

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