Use of medications among pregnant women in a city in the southern region of the Minas Gerais, Brazil

Authors

  • Vinícius Miranda Borges Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil
  • Fernanda Moura Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil
  • Cláudio Daniel Cerdeira Departamento de Bioquímica, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil. Rua Gabriel Monteiro da Silva, 700. CEP 37130-000, Alfenas, MG, Brasil. Phone +55-35-3292-2369.
  • Gérsika Bitencourt Santos Barros Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

DOI:

https://doi.org/10.14450/2318-9312.v30.e1.a2018.pp30-43

Keywords:

Pregnant women, drugs, risk groups

Abstract

This cross-sectional study identified, through home interviews, the pharmacotherapeutic profile of pregnant women attended at the Unified Health System (SUS) during the prenatal care. The drugs were classified according to the Food and Drug Administration (FDA) pregnancy risk categories. From the 104 respondents, 94.2% reported to use at least one drug during pregnancy, and were identified 53 different drugs, totalizing 316. The frequency of drugs from category A (n = 115, 36.4%) was closely related to B (n = 121, 38.3%) and 3 times higher than C (n = 36, 11.4%) and 4 than D (n = 29, 9.2%). 22.1% (CI(95%) 14.4 – 29.8) of the respondents used drugs from category D and 1.9% from X. There was a significant association between gestational age and drug use, so that 61.7% of the drugs were consumed in the third trimester of gestation, and 56.7% of the respondents consumed drugs at this period. The most commonly consumed therapeutic classes were vitamins/supplements/antianemics (35.33% from the 316; consumed by 72.97% of the interviewed), painkillers (14.6%; 44%), and antimicrobials (10.1%; 19.2%). The most frequently consumed drugs were folic acid (17.72% CI(95%) 13.67 - 22.39), ferrous sulfate (15.82% CI(95%) 11.98 - 20.32%), and paracetamol (12.97% CI(95%) 9.47 - 17.19). From the 104 respondents, 22% related smoking before pregnancy and 12.5% did not interrupt the habit during pregnancy, whereas 21 pregnant women related alcohol consumption before pregnancy and, 4 them, did interrupt the consumption during the gestational period. Therefore, this study reported a great number of
prescribed drugs to pregnant women, from all FDA pregnancy risk categories, including an outstanding use of drugs with a high teratogenic potential (D and X categories), and a considerable proportion of pregnant women using more
than one drug. The control and supervision during the use of drugs at the prenatal care must be taken into account, since the use of certain drugs during gestational period may lead to teratogenic damage and/or complications that
cause abort and impair the pregnant woman’s health. 

Author Biographies

Vinícius Miranda Borges, Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

Estudante de Medicina, Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

Fernanda Moura, Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

Estudante de Medicina, Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

Cláudio Daniel Cerdeira, Departamento de Bioquímica, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil. Rua Gabriel Monteiro da Silva, 700. CEP 37130-000, Alfenas, MG, Brasil. Phone +55-35-3292-2369.

Cláudio Daniel Cerdeira (CDC), B.Sc., M.Sc. (h-index = 2) is working as a researcher/scientist at the Biochemistry Department of the Biomedical Sciences Institute in the Federal University of Alfenas, MG, Brazil. He got his B.Sc. in Biomedical Sciences (2012) from Federal University of Alfenas. Then, he had completed his M.Sc. studies in program of Pharmaceutical Sciences at Federal University of Alfenas. In 2015, with scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil), he started his PhD studies (doctor's [Dr.Sc.] degree; pre-doc student) in Pharmaceutical Sciences at the same program. CDC has worked for 5 years with antimicrobial, cytotoxic, and antioxidant activities of natural compounds as well as with antimicrobial resistance (AMR) in microorganisms. He is working nowadays on the involvement of Protein Disulfide Isomerase (PDI), the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, and oxidative stress (influence of oxidants like reactive oxygen/nitrogen species [ROS/RNS] in pathophysiology of non-communicable (NCD, i.e., Diabetes mellitus [DM], dyslipidemia, and cardiovascular diseases [CVDs]) and inflammatory/infectious diseases, in cellular signalling, and influence of Low-level laser therapy (LLLT), antioxidants, and other compounds on immune response of phagocytic cells against pathogenic microorganisms of medical relevance (chiefly Staphylococcus aureus, Candida albicans, Mycobacterium tuberculosis, and Plasmodium falciparum). 

https://orcid.org/0000-0002-7242-8028

Gérsika Bitencourt Santos Barros, Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

Professora da faculdade de medicina.  Faculdade de medicina, Universidade José do Rosário Vellano (UNIFENAS), Rodovia Km 0, Bairro Trevo - MG 179 · (35) 3299-3000, Alfenas, 37130000, Minas Gerais (MG), Brasil

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Published

2018-04-09

How to Cite

Borges, V. M., Moura, F., Cerdeira, C. D., & Santos Barros, G. B. (2018). Use of medications among pregnant women in a city in the southern region of the Minas Gerais, Brazil. Infarma - Pharmaceutical Sciences, 30(1), 30–43. https://doi.org/10.14450/2318-9312.v30.e1.a2018.pp30-43

Issue

Vol. 30 No. 1 (2018)

Section

Original article

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