INTERACTIONS AMONG MEDICINES UNDER SPECIAL CONTROL IN THE DISTRICT PHARMACY CENTRO IN PORTO ALEGRE, RS, BRAZIL

Authors

  • Adriane Pasqualotto Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil
  • Paula Eliete Rodrigues Bitencourt Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Campus Centro, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 305, CEP 90050-170, Porto Alegre, RS, Brasil
  • Natália Azuaga Nietiedt Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil
  • Leonardo Fernandes De Paula Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil
  • Rafael de Oliveira Nogueira Centro de Saúde Santa Marta, Prefeitura Municipal, R. Cap. Montanha, 27 - Centro, 90010-040, Porto Alegre, Brasil
  • Rosane Gomez Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Campus Centro, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 305, CEP 90050-170, Porto Alegre, RS, Brasil

DOI:

https://doi.org/10.14450/2318-9312.v30.e3.a2018.pp146-151

Keywords:

prescriptions, psychotropics, health center, pharmaceutical attention, risk

Abstract

Polytherapy is a useful practice in the treatment of coexisting conditions or to enhance the pharmacological effect in less responsive conditions, but it presents a significant risk for drug interactions. Thus, the objective of this study was to identify in prescriptions issued by the Farmácia Distrital Centro in Porto Alegre, RS, possible drug interactions of medicines under special control and to classify them about potential drug interactions and degree of severity using the database MICROMEDEX®. After analyzing 2,839 prescriptions, the results showed that the majority of the patients were female and 75% of prescriptions presented some interaction. Out of 291 drug-drug associations analyzed. 44.4% gave a substantial risk of interaction, 23.9% moderate risk and 6.5% minor risk. Most of the strong-risk interactions showed cardiotoxicity as the main risk. The high frequency of interactions and the risk of toxic effects, also point to the need for an adequate information system on the use of medications as well as pharmaceutical guidance in these health facilities.

Author Biographies

Adriane Pasqualotto, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil

Farmacêutica generalista

Paula Eliete Rodrigues Bitencourt, Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Campus Centro, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 305, CEP 90050-170, Porto Alegre, RS, Brasil

Departamento de farmacologia

Área: farmácia, farmácia hospitalar, farmácia clínica, bioquímica clínica

Natália Azuaga Nietiedt, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil

Departamento de Farmacologia

Estudante do curso de farmácia, UFRGS

Leonardo Fernandes De Paula, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 - Azenha, CEP 90610-000, Porto Alegre, RS, Brasil

Departamento de farmacologia

Estudante de Farmácia, UFRGS

Rafael de Oliveira Nogueira, Centro de Saúde Santa Marta, Prefeitura Municipal, R. Cap. Montanha, 27 - Centro, 90010-040, Porto Alegre, Brasil

Farmacêutico

Rosane Gomez, Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Campus Centro, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 305, CEP 90050-170, Porto Alegre, RS, Brasil

Departamento de Farmacologia

Docente na disciplina de Farmacologia na UFRGS

Orientadora no Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, UFRGS.

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Published

2018-12-05

How to Cite

Pasqualotto, A., Rodrigues Bitencourt, P. E., Nietiedt, N. A., De Paula, L. F., Nogueira, R. de O., & Gomez, R. (2018). INTERACTIONS AMONG MEDICINES UNDER SPECIAL CONTROL IN THE DISTRICT PHARMACY CENTRO IN PORTO ALEGRE, RS, BRAZIL. Infarma - Pharmaceutical Sciences, 30(3), 146–151. https://doi.org/10.14450/2318-9312.v30.e3.a2018.pp146-151

Issue

Vol. 30 No. 3 (2018)

Section

Original article

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