The use of Cannabis sativa L. cannabinoids in the treatment of epilepsy: a narrative review

Authors

  • Lucas Alonso Lopes Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110
  • Bruno Paes De-Carli Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110
  • Caio Silva Moura Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110
  • Agatha Manzi Instituto de Biociências - Câmpus do Litoral Paulista (UNESP). Praça Infante Dom Henrique, s/n - Parque Bitaru, São Vicente-SP, 11330-900

DOI:

https://doi.org/10.14450/2318-9312.v34.e1.a2022.pp25-33

Keywords:

canabidiol, delta(9)-THC, convulsões, síndromes epilépticas, transtorno neurológico

Abstract

The use of Cannabis sativa for medicinal purposes is a very controversial subject in Brazil, so it is necessary to delve deeper into the theme to elucidate the main questions and possible benefi ts. Epilepsy is a disease
that causes neurological changes, such as epileptic seizures, dysphagia and convulsions. It can lead to cognitive and psychological damage and comorbidities, worsening the patient's quality of life. In this study an integrative review was carried out about the different types of C. sativa cannabinoids and their use for treating epilepsy. The data were obtained from research articles published in periodicals between 1963 and 2020. Special attention was given to different metabolites, such as cannabidiol (CBD). General aspects of epilepsy, phytocannabinoid use in refractory cases and clinical and pre-clinical trials were addressed in this review, emphasizing their biological effects. As a future target for treating epilepsy, the therapeutic use of CBD in neurology shows promising results in cases where the conventional medication has no effect. A contribution of research on other phytocannabinoids and their interrelationship is essential to advance the treatment of epilepsy and other pathologies.

Author Biographies

Lucas Alonso Lopes, Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110

Graduado em Ciências Biológicas na Universidade Paulista (UNIP) Campus Santos Rangel

Bruno Paes De-Carli, Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110

Graduado em Ciências Biológicas pela Universidade Santa Cecília (UNISANTA). Mestrado e Doutorado em Ciências Ambientais pela Universidade Estadual Paulista "Júlio de Mesquita Filho" Campus Sorocaba-SP.

Caio Silva Moura, Universidade Paulista (UNIP) Campus Santos Rangel Avenida Francisco Manoel s/n.º - Vila Matias, Santos - SP, 11075-110

Graduando em Ciências Biológicas na Universidade Paulista (UNIP) Campus Santos Rangel

Agatha Manzi, Instituto de Biociências - Câmpus do Litoral Paulista (UNESP). Praça Infante Dom Henrique, s/n - Parque Bitaru, São Vicente-SP, 11330-900

Graduada em Ciências Biológicas na Universidade Paulista (UNIP) Campus Santos Rangel. Mestranda em Biodiversidade Costeira no Instituto de Biociências - Câmpus do Litoral Paulista (UNESP), São Vicente-SP.

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Published

2022-04-08

How to Cite

Lopes, L. A., De-Carli, B. P., Moura, C. S., & Manzi, A. (2022). The use of Cannabis sativa L. cannabinoids in the treatment of epilepsy: a narrative review. Infarma - Pharmaceutical Sciences, 34(1), 25–33. https://doi.org/10.14450/2318-9312.v34.e1.a2022.pp25-33

Issue

Vol. 34 No. 1 (2022)

Section

Review Article

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