INHIBITION OF THE PRESERVATIVE SYSTEM OF TWO O/W EMULSIONS BY POLYSORBATE 80

Authors

  • Thalles Yuri Loiola Vasconcelos Instituto Superior de Teologia Aplicada. Rua Coronel Antonio Rodrigues Magalhães, Bairro Dom Expedito Lopes, 359, Sobral/CE.
  • Débora Patrícia Feitosa Medeiros Instituto Superior de Teologia Aplicada. Rua Coronel Antonio Rodrigues Magalhães, Bairro Dom Expedito Lopes, 359, Sobral/CE.
  • Aristides Ávilo do Nascimento Instituto Superior de Teologia Aplicada. Rua Coronel Antonio Rodrigues Magalhães, Bairro Dom Expedito Lopes, 359, Sobral/CE.

DOI:

https://doi.org/10.14450/2318-9312.v27.e4.a2015.pp221-225

Keywords:

cosmetic, cosmetic additives, cosmetic stability, parabens, polysorbates

Abstract

The inhibition of growth of microorganisms due to the bacteriostatic or ungistatic effect of the formulation may cause a false-negative result in microbiological analysis. Thus, the evaluation of the inhibitory capacity of the preservatives present in the sample is critical to an effective microbiological evaluation. The tests were performed to prove the absence of the inhibitory effect on the growth of microorganisms due to the inhibitory activity of these components. Inhibition of the formulation preservative effect was carried out by two methods: by the addition of 0.4 % polysorbate 80 and dilution. The sample was prepared using 10 g of each sample in 90 mL of 0.9 % saline, resulting in a 1:10 dilution. Also, it was added 0.4 % polysorbate 80 in saline solution to neutralize the parabens and imidazolidine in the formulations. The neutralization of the inhibitory effect was performed by using 0.4% polysorbate 80 and 1:10 dilution. It observed the growth of the following microorganisms: Staphylococcus aureus, Salmonella typhimurium, and Pseudomonas aeruginosa in all samples and the positive control, meaning the inactivation of the inhibitory effect of preservatives.

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Published

2016-01-06

How to Cite

Loiola Vasconcelos, T. Y., Feitosa Medeiros, D. P., & do Nascimento, A. Ávilo. (2016). INHIBITION OF THE PRESERVATIVE SYSTEM OF TWO O/W EMULSIONS BY POLYSORBATE 80. Infarma - Pharmaceutical Sciences, 27(4), 221–225. https://doi.org/10.14450/2318-9312.v27.e4.a2015.pp221-225

Issue

Vol. 27 No. 4 (2015)

Section

Original article

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