Standardization of the excipients in gelatine capsules hard of dry extract of valerian (Valeriana officinalis) produced in the Living Pharmacy Project in Sobral, CE, Brazil

Authors

  • Antônio Neudimar Bastos Costa Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.
  • Thalles Yuri Loiola Vasconcelos Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.
  • Tiago Sousa de Melo Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.
  • Patrícia Rodrigues Sousa Lima Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.
  • Renata Albuquerque Costa Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.
  • Aristides Ávilo do Nascimento Instituto Superior de Teologia Aplicada - INTA. Rua Coronel Antonio Rodrigues Magalhães, 359, Sobral, Ceará.

DOI:

https://doi.org/10.14450/2318-9312.v28.e2.a2016.pp105-112

Keywords:

excipients, medicinal plants, quality control, capsules

Abstract

The Living Pharmacy Project is the first pharmaceutical social assistance project developed in Brazil based on the scientific use of medicinal plants. Among the standardized formulations in hard gelatin capsules, stands out the dry extract of valerian. The formulation of these capsules requires an addition of excipients, which play a major role in the quality, safety, and efficacy of the drug. The purpose of this study was to standardize the excipients for capsule formulations produced in the Living Pharmacy Project. A bibliographic review was conducted, about excipients and herbal medicines, as well an analysis on the package leaflet of the medicines. Thirty capsules of the valerian herbal extract were produced and subjected to quality control to evaluate the average weight variation, including the coefficient of variation and standard deviation, and the variation in the theoretical contents of the capsules. The suggested excipients for using in the valerian formulation were: magnesium stearate (0.5 %) as a lubricant, colloidal silicon dioxide (1 %) as a glidant, pharmaceutical talc (1 %) as adsorbent, pharmaceutical starch (73 %) as a hydrophobic diluent, and lactose monohydrate (24.5 %) as a hydrophilic diluent. All quality
control results met the Brazilian Pharmacopoeia specifications.

Downloads

Published

2016-07-05

How to Cite

Costa, A. N. B., Vasconcelos, T. Y. L., Melo, T. S. de, Lima, P. R. S., Costa, R. A., & Nascimento, A. Ávilo do. (2016). Standardization of the excipients in gelatine capsules hard of dry extract of valerian (Valeriana officinalis) produced in the Living Pharmacy Project in Sobral, CE, Brazil. Infarma - Pharmaceutical Sciences, 28(2), 105–112. https://doi.org/10.14450/2318-9312.v28.e2.a2016.pp105-112

Issue

Vol. 28 No. 2 (2016)

Section

Original article

License

Authors who publish in this journal agree to the following terms:

 

  1. Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Licença Creative Commons Attribution which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
  2. Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (e.g. publish in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal.
  3. Authors are allowed and encouraged to publish and distribute their work online (e.g. in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and Citation of published work (See O Efeito do Acesso Livre ).