Gluconolactone as a potential active in the treatment of rosacea

Authors

  • Jully Silveira da Rosa Universidade do Vale do Itajaí - UNIVALI Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005
  • Sara Noemi Freitas Barth Universidade do Vale do Itajaí - UNIVALI Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005
  • Karina Elisa Machado UNIVALI - Universidade do Vale do Itajaí Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005

DOI:

https://doi.org/10.14450/2318-9312.v34.e1.a2022.pp34-44

Keywords:

rosacea, treatment, hydroxy acids

Abstract

Rosacea is an inflammatory and chronic disease that mainly affects the skin of the central facial region. It psychologically affects individuals, leading to decreased self-esteem, quality of life, and even depression. The disorder is characterized by erythema, edema, telangiectasia, hypertrophy of the sebaceous glands, redness and papules, which may also be accompanied by pustules and nodules, depending on disease evolution. The sensitivity and reactivity of skin with rosacea limits the therapeutic options, and one of
the promising options for its treatment is the use of gluconolactone acid, a polyhydroxy acid (PHA), characterized by a delta-lactone of glutamic acid. Gluconolactone is characterized by having antioxidant, humectant, anti-inflammatory, and skin barrier normalizing properties. In this perspective, this article aims to describe the active gluconolactone and analyze the benefits of its use in the treatment of rosacea, through a descriptive literature review, with a qualitative approach. The results demonstrate that using gluconolactone in the treatment of rosacea can be beneficial since it can act on erythema due to its humectant capacity, which temporarily strengthens the skin barrier function and decreases TEWL. Moreover, gluconolactone can improve skin sensitivity and background erythema due to anti-inflammatory activity. In addition, it can make telangiectasias less visible by increasing the production of hyaluronic acid, glycosaminoglycans, elastic fi bers, and collagen in the dermis. Together, these actions demonstrate the benefi ts of using gluconolactone in treating rosacea. 

Author Biographies

Jully Silveira da Rosa, Universidade do Vale do Itajaí - UNIVALI Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005

Cosmetóloga e Esteticista graduada pela Universidade do Vale do Itajaí – UNIVALI.

Sara Noemi Freitas Barth, Universidade do Vale do Itajaí - UNIVALI Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005

Cosmetóloga e Esteticista graduada pela Universidade do Vale do Itajaí – UNIVALI.

Karina Elisa Machado, UNIVALI - Universidade do Vale do Itajaí Endereço: Rodovia SC-401, 5025 - Saco Grande, Florianópolis - SC, 88032-005

 

Farmacêutica Estética e Bioquímica, atuante na área de Estética Avançada, com procedimentos minimamente invasivos. Habilitada em Farmácia Estética pelo Conselho Regional de Farmácia, atua com harmonização facial, utilizando técnicas de preenchimento facial, toxina botulínica, skinbooster, bioestimuladores, fios de sustentação, Intradermoterapia (Mesoterapia), Lipo de papada. Possui graduação em Farmácia pela Universidade do Vale do Itajaí (2002), Mestrado em Ciências Farmacêuticas pela Universidade do Vale do Itajaí (2005) e Doutorado em Pós-graduação em Farmácia pela Universidade Federal de Santa Catarina (2013). Além da atuação clínica é professora da UNIVALI em diferentes cursos e disciplina, com destaque as disciplinas de Cosmetologia Básica, Cosmetologia Aplicada, Cosmetologia Avançada, Anatomofisiologia e Trabalho de Conclusão de Curso.

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Published

2022-04-08

How to Cite

Rosa, J. S. da, Barth, S. N. F., & Machado, K. E. (2022). Gluconolactone as a potential active in the treatment of rosacea. Infarma - Pharmaceutical Sciences, 34(1), 34–44. https://doi.org/10.14450/2318-9312.v34.e1.a2022.pp34-44

Issue

Vol. 34 No. 1 (2022)

Section

Review Article

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