CRITICAL PARAMETERS FOR THE DEVELOPMENT OF STANDARDIZED DRY HERBAL EXTRACTS OBTAINED BY SPRAY-DRYING: FROM RESEARCH TO MANUFACTURING REALITY

Authors

  • Deise Cristina Drummond Xavier Paes Lopes Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0002-3223-697X
  • Caroline da Silva Pereira Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418.
  • Caroline Vianna Velasco Castilho Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0003-4596-3719
  • Márcia Pietroluongo Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0002-3944-6486
  • Ana Paula dos Santos Matos Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0002-2691-5335
  • Thiago Frances Guimarães Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0002-4534-6414
  • Alessandra Lifsitch Viçosa Laboratório de Farmacotécnica Experimental - Farmanguinhos, Fiocruz, Rua Sizenando Nabuco, 100- Manguinhos, Rio de Janeiro- RJ, Brasil. CEP 21041-000, Telefone: (21) 39772418. http://orcid.org/0000-0001-8511-0003

DOI:

https://doi.org/10.14450/2318-9312.v32.e4.a2020.pp391-403

Keywords:

parâmetros críticos, extratos secos vegetais, spray-drying, fitoterápicos

Abstract

Atomization or spray drying process is a frequent operation for obtaining dry extracts from medicinal plants. However, during the preparation of these herbal pharmaceutical active ingredients, several factors can affect the quality of intermediate products. Based on scientific literature and Brazilian legislation on herbal medicines, experiences of research and development (R & D) group from Fiocruz and brainstorming among team members, it designed a cause and effect diagram (Ishikawa Diagram). This work raises critical points in the production process of these herbal ingredients, indicating aspects of the spray-drying process by theoretical and practical sides that can affect the quality of herbal medicine. According to the discussion of each step described in the Ishikawa diagram to spray-dried extract preparation, it was possible to rationalize the production process of this intermediary with a focus on transforming it into an herbal product.

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Published

2020-12-08

How to Cite

Lopes, D. C. D. X. P., Pereira, C. da S., Castilho, C. V. V., Pietroluongo, M., Matos, A. P. dos S., Guimarães, T. F., & Viçosa, A. L. (2020). CRITICAL PARAMETERS FOR THE DEVELOPMENT OF STANDARDIZED DRY HERBAL EXTRACTS OBTAINED BY SPRAY-DRYING: FROM RESEARCH TO MANUFACTURING REALITY. Infarma - Pharmaceutical Sciences, 32(4), 391–403. https://doi.org/10.14450/2318-9312.v32.e4.a2020.pp391-403

Issue

Vol. 32 No. 4 (2020)

Section

Technical Note

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