NEUROPROTECTIVE ACTIVITY OF MINOCYCLINE IN CEREBRAL ISCHEMIA: SYSTEMATIC REVIEW

Authors

  • Jean Pierre de Oliveira Alencar Farmacêutico Generalista. Graduado na Faculdade de Juazeiro do Norte – FJN. Rua São Francisco, 1224, Bairro São Miguel, Juazeiro do Norte, CEP: 63010-475. Ceará. Brasil. http://orcid.org/0000-0003-3443-9604
  • Gustavo de Oliveira Alencar Farmacêutico Generalista. Graduado na Faculdade de Juazeiro do Norte – FJN. Rua São Francisco, 1224, Bairro São Miguel, Juazeiro do Norte, CEP: 63010-475. Ceará. Brasil. http://orcid.org/0000-0001-6330-4966
  • Iri Sandro Pampolha Lima Docente da Universidade Federal do Cariri -UFCA. Departamento de Medicina. Rua Divino Salvador, 284, Bairro Centro, Barbalha, CEP: 63180000. Ceará. Brasil. http://orcid.org/0000-0001-6652-952X

DOI:

https://doi.org/10.14450/2318-9312.v31.e3.a2019.pp146-154

Keywords:

Activity. Ischemia. Minocycline. Neuroprotection

Abstract

Stroke is caused by interruption of cerebral blood flow and may be of ischemic genesis. The subtypes are determined according to the origin, being: atherosclerosis of large arteries, cardioembolism, occlusion of small arteries, of other determined origins and unknown origin. The pharmacological treatment is the Tissue Plasminogen Activator, of narrow therapeutic window. Minocycline can cross the blood-brain barrier, acting on neuronal loss, becoming a neuroprotective potential of high applicability and specificity, blocking cellular groups responsible for the inflammatory and degenerative process. The objective was carry on a systematic review. The used, with the descriptors: minociclina/neuroproteção and minocycline/neuroprotection, only sevem studies were selected, published between 2014 and 2018 available in full for free. Minocycline correlates with inhibition of NF-κB in neurons, antioxidant, has anti-apoptotic effect, improvement in tissue damage, functional recovery in animals, involvement with MCP1P1, and correlation
with factor factors CREB, pCREB, and BDNF. The ability of neuroprotection obtained through minocycline treatment in ischemic models is remarkable. This promising therapy is definitively proven.

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Published

2019-10-07

How to Cite

Alencar, J. P. de O., Alencar, G. de O., & Lima, I. S. P. (2019). NEUROPROTECTIVE ACTIVITY OF MINOCYCLINE IN CEREBRAL ISCHEMIA: SYSTEMATIC REVIEW. Infarma - Pharmaceutical Sciences, 31(3), 146–154. https://doi.org/10.14450/2318-9312.v31.e3.a2019.pp146-154

Issue

Vol. 31 No. 3 (2019)

Section

Review Article

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