PHARMACEUTICAL EQUIVALENCE STUDY BETWEEN SIMILAR AND GENERIC FUROSEMIDE PILLS

Authors

  • Murilo Neth de Sousa Centro Universitário Ingá - Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510
  • Thalita Prates da Silva Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900
  • Emilly Isabelli dos Santos Teodoro Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900
  • Mariana Aparecida Lopes-Ortiz Centro Universitário Ingá- Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510
  • João Carlos Palazzo de Mello Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900
  • Daniela Cristina de Medeiros Araújo Centro Universitário Ingá - Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510

DOI:

https://doi.org/10.14450/2318-9312.v32.e1.a2020.pp77-85

Keywords:

pharmaceutical equivalence, furosemide, generic, similar drug

Abstract

Furosemide is a medicine widely used in hypertensive therapy, congestive heart failure, oedema of cardiac, renal and hepatic origin. Because it is a loop diuretic, due to its role in the thick segment of the Henle loop, it is considered very potent for these diseases. Pharmaceutical equivalence aims to promote comparative quality tests between the reference drug and the drug to be tested. Test and reference medicinal products must present the same concentrations, pharmaceutical forms, physical and physicochemical characteristics. In this study, the drug furosemide 40 mg was used, where two generic brands were tested (G1 and G2), and two similar ones (S1 and S2) comparing them with the reference (R). Regarding weight variation, friability, disintegration, hardness, dissolution, dosing and the total number of mesophilic microorganisms, it can be said that the drugs are pharmaceutical equivalents.

Author Biographies

Murilo Neth de Sousa, Centro Universitário Ingá - Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510

Aluno de graduação do Centro Universitário Ingá - Uningá

Thalita Prates da Silva, Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900

Aluna do Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Estadual de Maringá

Emilly Isabelli dos Santos Teodoro, Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900

Aluna do Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Estadual de Maringá

Mariana Aparecida Lopes-Ortiz, Centro Universitário Ingá- Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510

Professora Adjunta do Centro Universitário Ingá - Uningá

João Carlos Palazzo de Mello, Universidade Estadual de Maringá Av. Colombo, 5790 - Zona 7, Maringá - PR, 87020-900

Departamento de Farmácia

Daniela Cristina de Medeiros Araújo, Centro Universitário Ingá - Uningá Rod. PR 317, 6114 Parque Industrial 200, Maringá - PR, 87035-510

Professora adjunta do curso de Farmácia

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Published

2020-06-01

How to Cite

Sousa, M. N. de, Silva, T. P. da, Teodoro, E. I. dos S., Lopes-Ortiz, M. A., Mello, J. C. P. de, & Medeiros Araújo, D. C. de. (2020). PHARMACEUTICAL EQUIVALENCE STUDY BETWEEN SIMILAR AND GENERIC FUROSEMIDE PILLS. Infarma - Pharmaceutical Sciences, 32(1), 77–85. https://doi.org/10.14450/2318-9312.v32.e1.a2020.pp77-85

Issue

Vol. 32 No. 1 (2020)

Section

Original article

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