DOSE ADJUSTMENT OF MEDICINES ACCORDING TO RENAL FUNCTION IN A UNIVERSITY HOSPITAL

Authors

  • Gisele Araújo Rodrigues Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Jessica Wedna da Silva Alves Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Regina Meira Lima de Souza Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Laís Silva de Vasconcelos Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Celuane Alves Moura Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Ricardo Brandão Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901
  • Francisca Sueli Monte Moreira Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

DOI:

https://doi.org/10.14450/2318-9312.v33.e3.a2021.pp269-275

Keywords:

renal elimination, creatinine, drug prescriptions, medication error, glomerular filtration rate.

Abstract

This study evaluated the need for dose adjustment of medications according to the renal function of patients in the medical clinic in a university hospital in the State of Pernambuco, Brazil. The study follows a cross-sectional design. The prescriptions of patients hospitalized from September 2019 to February 2020 were analyzed. The study follows a retrospective longitudinal design. The prescriptions of patients hospitalized from September 2019 to February 2020 were analyzed. During this period, 245 patients had 
their prescriptions evaluated. Of these, 45 patients (18.3%) were excluded due to the absence of creatinine information and 152 (62.0%) because they did not require adjustment of the dose of medication because renal function was within normal parameters. The remaining 48 patients were included in the final study, because they presented altered renal function and used renal excreted drugs. It was found that 60.4% received at least one prescription during hospitalization with an unadjusted dose of medication according to
renal function. Among the drugs with unadjusted doses, antimicrobials were the most frequent. This study warns of the importance of monitoring renal function, especially when prescription drugs excreted renally.

Author Biographies

Gisele Araújo Rodrigues, Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Farmácia Clínica - Hospital das Clínicas da Universidade Federal de Pernambuco

Jessica Wedna da Silva Alves, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Departamento de Farmácia da Universidade Federal de Pernambuco

Regina Meira Lima de Souza, Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Farmácia Clínica - Hospital das Clínicas da Universidade Federal de Pernambuco

Laís Silva de Vasconcelos, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Farmácia Clínica - Hospital das Clínicas da Universidade Federal de Pernambuco

Celuane Alves Moura, Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Farmácia Clínica - Hospital das Clínicas da Universidade Federal de Pernambuco

Ricardo Brandão, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Departamento de Farmácia da Universidade Federal de Pernambuco

Francisca Sueli Monte Moreira, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901

Departamento de Farmácia da Universidade Federal de Pernambuco

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Published

2021-10-05

How to Cite

Rodrigues, G. A., da Silva Alves, J. W., Lima de Souza, R. M., de Vasconcelos, L. S., Moura, C. A., Brandão, R., & Monte Moreira, F. S. (2021). DOSE ADJUSTMENT OF MEDICINES ACCORDING TO RENAL FUNCTION IN A UNIVERSITY HOSPITAL. Infarma - Pharmaceutical Sciences, 33(3), 269–275. https://doi.org/10.14450/2318-9312.v33.e3.a2021.pp269-275

Issue

Vol. 33 No. 3 (2021)

Section

Original article

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