ANTIBIOTIC THERAPY WITH Β-LACTAMIC INHIBITORS FOR RE-SENSIBILIZATION OF MULTI-RESISTANT BACTERIA

Authors

  • Kledson Lopes Barbosa Hospital Universitário Professor Alberto Antunes - HUPAA - UFAL Av. Lourival Melo Mota, s/n Tabuleiro do Martins Maceió - AL CEP:57072-900
  • Fábio Ferreira de Araújo Centro Universitário Augusto Motta Rua Olindina Campos Teixeira, 93 Jatiúca, Maceió-AL CEP: 57036-690
  • Dênis Fagner Souza Lins Centro Universitário Augusto Motta Rua Olindina Campos Teixeira, 93 Jatiúca, Maceió-AL CEP: 57036-690

DOI:

https://doi.org/10.14450/2318-9312.v32.e4.a2020.pp329-335

Keywords:

antibiotics, antimicrobial, β-lactam, co-administration, bacterial resistance

Abstract

Indiscriminate use of antibiotics generally provided the development of several multiresistant bacteria, which are responsible for systemic infections of great clinical importance. This study described in a narrative way the antibiotic resistance to β-lactams and their administration combined with others drugs aiming at the bacterial resensitization of multidrug-resistant strains. It is a qualitative study of narrative review, consisting of an analysis of the literature with a search of data published in the database  ScienceDirect on use of β-lactam inhibitors for treating infections caused by multiresistant bacteria. We showed that there are possibilities of treatment of bacterial infections caused by multiresistant strains by antibiotic therapy of β-lactam inhibitors. Multidrug-resistant bacterial infections remain a major challenge for medicine, as enzymes confer bacterial resistance to all antibiotics. Even though there are currently available inhibitors of β-lactamases and microbial activity, it is necessary that the effort to find new antibiotics is continuous for the control of multiresistant bacteria.

Author Biographies

Kledson Lopes Barbosa, Hospital Universitário Professor Alberto Antunes - HUPAA - UFAL Av. Lourival Melo Mota, s/n Tabuleiro do Martins Maceió - AL CEP:57072-900

Doutor em Ciências (Bioquímica) e Analista Clínico no Departameto de Imunohematologia da Unidade Transfusional HUPAA/UFAL

Fábio Ferreira de Araújo, Centro Universitário Augusto Motta Rua Olindina Campos Teixeira, 93 Jatiúca, Maceió-AL CEP: 57036-690

Farmacêutico e Pós-graduando em Farmácia Clínica e Prescrição Farmacêutica

Dênis Fagner Souza Lins, Centro Universitário Augusto Motta Rua Olindina Campos Teixeira, 93 Jatiúca, Maceió-AL CEP: 57036-690

Farmacêutico e Pós-graduando em Farmácia Clínica e Prescrição Farmacêutica

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Published

2020-12-08

How to Cite

Barbosa, K. L., Araújo, F. F. de, & Lins, D. F. S. (2020). ANTIBIOTIC THERAPY WITH Β-LACTAMIC INHIBITORS FOR RE-SENSIBILIZATION OF MULTI-RESISTANT BACTERIA. Infarma - Pharmaceutical Sciences, 32(4), 329–335. https://doi.org/10.14450/2318-9312.v32.e4.a2020.pp329-335

Issue

Vol. 32 No. 4 (2020)

Section

Review Article

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