Analysis of adverse reactions reported spontaneously by pharmacists in a teaching hospital in Ceará
DOI:
https://doi.org/10.14450/2318-9312.v37.e1.a2025.pp88-103Keywords:
Pharmacovigilance, Drug-Related Side Effects and Adverse Reactions, PharmacistsAbstract
Pharmacovigilance has as one of its main objectives the detection of adverse drug reactions (ADR), which
are considered a serious public health problem contributing to increased morbidity and mortality. The method most used by pharmacovigilance to identify ADR is spontaneous reporting, due to its simplicity and low cost. This study aimed to analyze ADRs reported by pharmacists in a teaching hospital. A cross-sec-tional, descriptive, retrospective study was carried out, where information was collected on ADRs reported by pharmacists to the Patient Safety Center from January 1, 2020 to December 31, 2022. CEP/HUWC: 5,409,579. Of the 172 ADRs reported, 140 (81%) were performed by pharmacists, corresponding to 73 patients, 56.1% (43) female, with a mean age of 45.9 years, 48.6% (68) were hospitalized in clinical wards. The majority of ADRs (30.7%, N= 43) promoted disorders of the cutaneous and subcutaneous tissues, the most frequent reaction was pruritus 16.4% (23). Regarding the ATC classification, anti-infective drugs for systemic use received 90 notifications (62.1%), with polymyxin B being the most prevalent in notifications, 17.1% (24). Regarding causality, 70.7% (99) of ADRs were considered possible and regarding severity, 121 (86.4%) were mild. One of the main limiting factors of the study was underreporting. In this scenario, the pharmacist stands out as a healthcare professional who spontaneously reports many adverse drug reactions (ADRs), contributing to increased patient safety.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Ingrid Peixoto Furtado, Andreína Fontenele Teixeira, Júlio César Castro Silva, Maria Gabrielle Oliveira e Silva Linhares, Patrícia Bastos Luz, Luciana Mabel Ferreira Vasconcelos Félix, José Martins de Alcantara Neto, Alisson Menezes Araújo Lima
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Licença Creative Commons Attribution which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
- Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (e.g. publish in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal.
- Authors are allowed and encouraged to publish and distribute their work online (e.g. in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and Citation of published work (See O Efeito do Acesso Livre ).
