PRELIMINAR EVALUATION OF STABILITY OF NON-IONIC EMULSION CONTAINING KOJIC ACID 2.0% FROM COMPOUNDING PHARMACIES
DOI:
https://doi.org/10.14450/2318-9312.v25.e4.a2013.pp193-198Keywords:
Kojic Acid, Emulsions, Pharmaceutical Compounding, Stability StudyAbstract
Emulsions containing kojic acid are common to be used in skin whitening treatments. In this work, it was evaluated the preliminary stability of non-ionic lotions containing 2.0 % kojic acid produced in compounding pharmacies. The products were acquired from four compounding pharmacies in Porto Alegre city. The samples, in polyethylene flasks, were submitted to storage at 25 and 45ºC and analyzed at periods of zero, 7, 15, 30 and 60 days. The samples were evaluated in order to determine the organoleptic characteristics, pH, centrifugation test and weight of storage flasks.The organoleptic profile was modified after 7 days of storage for samples at 45 ºC. For pH, samples at 45 ºC presented a reduction in the values, with an increase in acidity at the time. In this case, the sample centrifugation did not influence in this parameter, neither led to phase separation. For weight determination, the results demonstrated a modification in the samples stored at 45 ºC, which illustrate the importance to have attention for storage material. The proposed assays emphasize the importance of stability studies of cosmetic products containing kojic acid, mainly considering the formulation and the product storage conditions.
Downloads
Published
2013-12-30
How to Cite
Viegas, C. R., & Mendez, A. S. L. (2013). PRELIMINAR EVALUATION OF STABILITY OF NON-IONIC EMULSION CONTAINING KOJIC ACID 2.0% FROM COMPOUNDING PHARMACIES. Infarma - Pharmaceutical Sciences, 25(4), 193–198. https://doi.org/10.14450/2318-9312.v25.e4.a2013.pp193-198
Issue
Section
Technical Note
License
Authors who publish in this journal agree to the following terms:
- Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Licença Creative Commons Attribution which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
- Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (e.g. publish in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal.
- Authors are allowed and encouraged to publish and distribute their work online (e.g. in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and Citation of published work (See O Efeito do Acesso Livre ).