STUDY OF THE EFFECTS OF VINPOCETINE ON INDICATORS OF ACID-ALKALINE STATE FOLLOWING THE ISCHEMIC BRAIN DAMAGE

Authors

  • Larisa M. Makarova Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai http://orcid.org/0000-0002-2040-7428
  • Vasily E. Pogorely Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai http://orcid.org/0000-0002-7651-3633
  • Irina L Abisalova Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai http://orcid.org/0000-0002-3828-6759
  • Olga V Kharitonova Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai, http://orcid.org/0000-0001-7840-9269
  • Tamara I. Makarova 2 Pyatigorsk State University prosp. Kalinina 9, Pyatigorsk, 357532 Russia http://orcid.org/0000-0001-5388-7408
  • Tatiana E. Onbysh Kuban State Medical University 4 Mitrofan Sedina str. PO BOX. 350063. Krasnodar, Russian Federation http://orcid.org/0000-0002-1390-0484
  • Nina E. Kosyanok Kuban State Agrarian University named after I.T. Trubilin, st. Kalinina, 13 Krasnodar. PO BOX 350044. Krasnodar, Russian Federation http://orcid.org/0000-0002-9371-8147

DOI:

https://doi.org/10.14450/2318-9312.v35.e1.a2023.pp41-51

Keywords:

vinpocetine, cerebral ischemia, reperfusion, acid-base state, carbon dioxide tension

Abstract

Vinpocetine is a multipurpose medicine with several pharmacological targets. It is known for its neuroprotective properties. Its mechanism of action in brain pathology is due to a selective inhibitor of phosphodiesterase type 1, inhibition of voltage-gated sodium channels, and a decrease in calcium influx into neurons. Vinpocetine combines high clinical efficacy and safety of use. Therefore it successfully competes in the pharmaceutical market with an ever-increasing number of new medicines. The purpose of the work was to experimentally study the effects of vinpocetine in cats at a dose of 5 mg/kg on the indicators of the acid-base state (ABS) of arterial and venous blood in the simulation of total cerebral ischemia. The effect of vinpocetine on acid-base status indicators should be considered as the most important aspect of its action, contributing to the neuroprotective effect. The paper discusses possible molecular targets and mechanisms for implementing the protective effect of vinpocetine in ischemia, considering its favorable effect on ABS. These new findings may point to increased use of vinpocetine in human cardiovascular diseases accompanied by ABS deterioration.

Author Biographies

Larisa M. Makarova, Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai

PhD in Pharmacy

Vasily E. Pogorely, Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai

Doctor of Biological Sciences

Irina L Abisalova, Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai

PhD in Pharmacy

Olga V Kharitonova, Pyatigorsk Medical and Pharmaceutical Institute, branch of the Volgograd State Medical University Address: 11 Kalinina avenue, Pyatigorsk, PO BOX 357501. Stavropol Krai,

Ph.D. in Medical Sciences

Tamara I. Makarova, 2 Pyatigorsk State University prosp. Kalinina 9, Pyatigorsk, 357532 Russia

PhD in Biology

Tatiana E. Onbysh, Kuban State Medical University 4 Mitrofan Sedina str. PO BOX. 350063. Krasnodar, Russian Federation

PhD in Pharmacy

Nina E. Kosyanok, Kuban State Agrarian University named after I.T. Trubilin, st. Kalinina, 13 Krasnodar. PO BOX 350044. Krasnodar, Russian Federation

PhD in Pharmacy

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Published

2023-04-24

How to Cite

Makarova, L. M., Pogorely, V. E., Abisalova, I. L., Kharitonova, O. V., Makarova, T. I., Onbysh, T. E., & Kosyanok, N. E. (2023). STUDY OF THE EFFECTS OF VINPOCETINE ON INDICATORS OF ACID-ALKALINE STATE FOLLOWING THE ISCHEMIC BRAIN DAMAGE. Infarma - Pharmaceutical Sciences, 35(1), 41–51. https://doi.org/10.14450/2318-9312.v35.e1.a2023.pp41-51

Issue

Vol. 35 No. 1 (2023)

Section

Original article

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